| Autor: |
Narita, Minoru, Kuzumaki, Naoko, Narita, Michiko, Kaneko, Chihiro, Hareyama, Nana, Miyatake, Mayumi, Shindo, Keiko, Miyoshi, Kan, Nakajima, Mayumi, Nagumo, Yasuyuki, Sato, Fumiaki, Wachi, Hiroshi, Seyama, Yoshiyuki, Suzuki, Tsutomu |
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| Zdroj: |
Journal of Neurochemistry; Jun2006, Vol. 97 Issue 5, p1369-1378, 10p, 1 Color Photograph, 3 Black and White Photographs, 5 Graphs |
| Abstrakt: |
It has been widely recognized that chronic pain could cause physiological changes at supraspinal levels. The δ-opioidergic system is involved in antinociception, emotionality, immune response and neuron-glia communication. In this study, we show that mice with chronic pain exhibit anxiety-like behavior and an increase of astrocytes in the cingulate cortex due to the dysfunction of cortical δ-opioid receptor systems. Using neural stem cells cultured from the mouse embryonic forebrain, astrocyte differentiation was clearly observed following long-term exposure to the selective δ-opioid receptor antagonist, naltrindole. We also found that micro-injection of either activated astrocyte or astrocyte-conditioned medium into the cingulate cortex of mice aggravated the expression of anxiety-like behavior. Our results indicate that the chronic pain process promotes astrogliosis in the cingulate cortex through the dysfunction of cortical δ-opioid receptors. This phenomenon may lead to emotional disorders including aggravated anxiety under chronic pain-like state. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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