| Autor: |
Hasson, Eilat, Gallula, Jeniffer, Shimoni, Yael, Grad-Itach, Etty, Marikovsky, Moshe, Mitrani, Eduardo |
| Předmět: |
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| Zdroj: |
Journal of Vascular Research; 2006, Vol. 43 Issue 2, p139-148, 10p, 2 Color Photographs, 3 Black and White Photographs, 1 Chart, 1 Graph |
| Abstrakt: |
We have recently reported an alternative cell therapy approach to induce angiogenesis. The approach is based on small organ fragments – micro-organs (MOs) – whose geometry allows preservation of the natural epithelial/mesenchymal interactions and ensures appropriate diffusion of nutrients and gases to all cells. We have shown that lung-derived MOs, when implanted into hosts, transcribe a wide spectrum array of angiogenic factors and can induce an angiogenic response that can rescue experimentally induced ischemic regions in mice.From a clinical perspective, skin-derived MOs are particularly appealing as they could readily be obtained from a skin biopsy taken from the same target patient. In the present work we have investigated the angiogenesis-inducing capacity of rabbit and human skin-derived micro-organs in vitro and in vivo. Rabbit skin MOs were implanted into homologous adult rabbits and human skin MOs were encapsulated and implanted into xenogenic mice. Skin-derived MOs, as lung-derived MOs, were found to secrete a whole array of angiogenic factors and to induce a powerful angiogenic response when implanted back into animals. We believe the approach presented suggests a novel, efficacious and simple approach for therapeutic angiogenesis. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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