| Autor: |
Tanaka, Toshiyuki, Kyo, Masahiro, Kokado, Yukito, Takahara, Shiro, Hatori, Motoaki, Suzuki, Kazuhiro, Hasumi, Masaru, Toki, Kiyohide, Ichimaru, Naotsugu, Yazawa, Koji, Hanafusa, Torn, Namba, Yukiomi, Oka, Kazumasa, Moriyama, Toshiki, Imal, Enyu, Okuyama, Akihiko, Yamanaka, Hidetoshi |
| Předmět: |
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| Zdroj: |
Transplant International; Feb2005, Vol. 17 Issue 2, p59-64, 6p |
| Abstrakt: |
The 1997 fourth Banff meeting revised the consensus for describing transplant biopsies. We have conducted a retrospective analysis of biopsies correlated between the Banff 97 classification and clinical outcome. The patients (n = 149), who had a total of 404 biopsy-proven rejections, were assessed and the biopsies taken from these patients were re-examined and classified according to the Banff 97 classification. Morphological changes in the glomeruli (g), interstitium (1), tubules(t), and arterial vessels (v) were scored. Severity of acute rejection was statistically associated with unresponsiveness to anti-rejection treatment (P < 0.0001) and predicted an increased risk of graft failure (P < 0.05). Each quantitative criterion (g, i, t, and v) was also statistically associated with unresponsiveness to anti-rejection treatment. Mean serum creatinine levels were significantly higher in the groups graded Banff 97 type I-Ill after 1 and 2 years of follow-up. The Banff 97 classification correlated with reversibility of rejection episodes and long-term graft survival. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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