| Autor: |
Sifakis, Stavros, Angelakis, Emmanuel, Vardaki, Elpida, Fragouli, Yvoni, Koumantakis, Eugenios |
| Předmět: |
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| Zdroj: |
Archives of Gynecology & Obstetrics; Sep2005, Vol. 272 Issue 3, p183-186, 4p |
| Abstrakt: |
Aim: The aim of this study was to evaluate the efficacy and tolerance of a high dose of vaginal misoprostol for outpatient medical management of missed abortion. Methods: Three doses of 400 µg misoprostol were administered intravaginally every 4 h daily, for a maximum period of 3 days, to 108 women with uneventful first trimester pregnancy failure. Results: A total of 98 women (90.7%) were managed successfully, with 74 (68.5%) of them within the first 24 h. The mean dose of misoprostol administered was 1,113.0 µg (range 400-3,600 µg), and the mean time required was 19.5 h (range 7-65 h). Only 6 out of 108 women (9.3%) required surgical intervention as the result of retained products of conception. The side effect profile was minimal. Conclusion: This protocol of 400 µg intravaginally misoprostol every 4 h as three daily doses for a maximum of 3 days, may offer an efficacious and safe alternative to the outpatient management of first-trimester missed abortion. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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