Effects of Dietary Supplementation of DL-Methionine or DL-Methionine Hydroxyl Analogue (MHA-Ca) on Growth Performance and Blood and Liver Redox Status in Growing Pigs.

Autor: Oladejo, Emmanuel O., Hasan, Md Shamimul, Sotak, Susan C., Htoo, John K., Brett, James, Feugang, Jean M., Liao, Shengfa F.
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Zdroj: Animals (2076-2615); Dec2024, Vol. 14 Issue 23, p3397, 11p
Abstrakt: Simple Summary: This study aimed to compare the protective roles of two commercial methionine (Met) products, DL-Met and MHA-Ca, supplemented at an equal bioefficacy level in the diets of growing pigs. The results showed that the diquat injection in pigs induced oxidative stress by reducing growth performance and antioxidative status. Although supplementing with 25% more DL-Met than the NRC (2012) recommendation did not improve growth performance, it enhanced the pigs' antioxidative status. Additionally, this study indicated no differences in the influence of MHA-Ca vs. DL-Met on the growth performance and antioxidative status in these pigs. These findings suggest that both Met products similarly affected the antioxidative status of the pigs. Oxidative stress impairs pigs' health and production performance. This study examined the effects of level and source of methionine (Met) supplementation against the diquat-induced oxidative stress in pigs. Forty growing barrows were randomly assigned to four groups. Groups 1 and 2 received a basal diet that was adequate in energy and nutrients (Diet 1), Group 3 received a DL-Met-supplemented diet, and Group 4 received an MHA-Ca-supplemented diet. After 3 weeks of feeding (Phase 1), pigs were injected with 10 mL saline (Group 1) or 10 mg/kg-BW diquat in 10 mL saline (Groups 2, 3, and 4), and then continually fed for one week (Phase 2). During or at the end of Phase 1, there were no differences in nearly all of the growth performance and redox parameters among the four groups. During or at the end of Phase 2, however, the ADFI and ADG were lower (p < 0.01) in Group 2 than in Group 1 while the serum malondialdehyde content was higher (p < 0.05) in Group 2 than in Group 1. The serum glutathione peroxidase (GPX) activity and liver superoxide dismutase (SOD) activity were lower (p < 0.05) in Group 2 than in Group 1. The serum GPX activity, the serum total antioxidant capacity, and the liver GPX activity were higher (p < 0.05) in Group 3 than in Group 2. There were nearly no differences in these redox parameters between Groups 3 and 4. In conclusion, MHA-Ca and DL-Met, when used at an equivalent bioefficacy level, had similar effects on the pigs' growth performance and antioxidative status. Therefore, increased Met supplementation can improve pigs' antioxidative status. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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