| Autor: |
Mangalam, Ashutosh, Wahls, Terry L., Shemirani, Farnoosh, Titcomb, Tyler J., Snetselaar, Linda G., Eyck, Patrick Ten, Rubenstein, Linda M., Meza, Leeann Aguilar, Fitzjerrels, Rachel |
| Zdroj: |
International Journal of MS Care; 2024 Supplement, Vol. 26, p96-97, 2p |
| Abstrakt: |
BACKGROUND: Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease treated with disease-modifying therapies. Recently, dietary intervention has emerged as a potential adjunct treatment for MS, but the mechanism through which diet imparts its beneficial effects is poorly understood. The Wahls (modified Paleolithic elimination) and Swank (low saturated fat) diets are 2 popular diets in the MS community that have previously been shown to reduce fatigue and improve quality of life (QOL) among people with MS (PwMS). OBJECTIVES: As diet significantly affects the gut microbiota, we aimed to investigate whether the beneficial effect of Wahls and Swank diets in PwMS is mediated through the modulation of gut microbiota. Specifically, we asked whether diet-induced changes in gut microbiota play a role in the diet's symptom-modulating impacts. METHODS: Fecal microbiota were profiled using 16S-based ribosomal RNA sequencing of the V3-V4 region. As gut microbiome homeostasis is dependent on the microbial ecosystem dynamics, we utilized an unsupervised machine learning approach to identify communities of bacteria linked to clinically significant outcome improvement. RESULTS: In a subset of participants with MS from a completed dietary intervention study (27 using Wahls and 35 using Swank), we identified several baseline microbiome communities significantly associated with a 24-week improved outcome response in the Wahls diet for fatigue (Fatigue Severity Scale metric), mental QOL, and physical QOL and in the Swank diet for fatigue (Fatigue Severity Scale metric) and mental QOL. The composition of the gut microbiome at baseline in this study appears to predict how well an individual will respond to the Wahls or Swank diet in terms of fatigue or QOL. In general, most participants with a baseline microbiome (prior to diet) containing low abundances of Prevotella and an enrichment of Bacteroides, Alistipes, Parabacteroides, and Faecalibacterium saw symptom improvement after 24 weeks following these diets. CONCLUSIONS: The inverse correlation between the abundance of Prevotella and symptom improvement highlights the importance of gut microbiota in relation to dietary interventions and suggests the potential for tailoring dietary interventions based on an individual's gut bacteria profile. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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