Lewis Acid Catalyzed Domino Ring-Opening Cyclization of Azetidines with Alkynes: Synthesis of Tetrahydropyridines.

Autor: Shukla, Dipti, Singh, Shishir, Sharma, Amit Kumar, Singh, Bharat, Bhattacharyya, Aditya, Talukdar, Ranadeep, Ghorai, Manas K.
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Zdroj: Synlett; Dec2024, Vol. 35 Issue 20, p2459-2464, 6p
Abstrakt: A simple strategy for the synthesis of a variety of tetrahydropyridines in good to excellent yields via a Cu(OTf)2 catalyzed quaternary ammonium salt mediated ring-opening of activated azetidines followed by cyclization with alkynes in a domino ring-opening cyclization (DROC) is described. The formation of the products has been explained by an SN 2-type ring-opening of azetidines with alkynes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index