| Autor: |
Katagiri, Takamasa, Takahashi, Rio, Zaimoku, Yoshitaka, Hosokawa, Kohei, Ogawa, Seishi, Takahashi, Yoshiyuki, Miyamura, Takako, Onishi, Yasushi, Koike, Takashi, Nishida, Tetsuya, Uchida, Naoyuki, Doki, Noriko, Tanaka, Masatsugu, Eto, Tetsuya, Itagaki, Mitsuhiro, Sawa, Masashi, Fukuda, Takahiro, Onizuka, Makoto, Atsuta, Yoshiko, Nakao, Shinji |
| Předmět: |
|
| Zdroj: |
British Journal of Haematology; Nov2024, Vol. 205 Issue 5, p2084-2088, 5p |
| Abstrakt: |
The article explores the correlation between genomic alterations and clinical features of hepatitis-associated aplastic anaemia (HAAA), focusing on the loss of HLA class I allele expression in male patients. The study found a higher prevalence of certain high-risk HLA alleles, particularly HLA-B*40:02, in patients with HAAA compared to those with idiopathic aplastic anaemia (iAA). The research sheds light on the immunopathological mechanisms underlying HAAA and emphasizes the significance of HLA-B*40:02 in the development of this condition, particularly in young men. Further studies are needed to deepen our understanding of the molecular pathogenesis of HAAA. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text