Mycobacterium w - a promising immunotherapeutic intervention for diseases.

Autor: Stefan, Kirsten, Gordon, Ryan, Rolig, Annah, Honkala, Alexander, Tailor, Dhanir, Davis, Lara E., Modi, Rajiv I., Joshipura, Manjul, Khamar, Bakulesh, Malhotra, Sanjay V.
Předmět:
Zdroj: Frontiers in Immunology; 2024, p1-20, 20p
Abstrakt: Immunomodulating agents interact with the immune system and alter the outcome of specific immune processes. As our understanding of the immune system continues to evolve, there is a growing effort to identify agents with immunomodulating applications to use therapeutically to treat various diseases. Mycobacterium w (Mw), a heat-killed mycobacterium, is an atypical mycobacterial species that possesses strong immunomodulatory properties. Mw was initially evaluated as an immune-therapeutic against leprosy, but since then Mw has generated a lot of interest and been studied for therapeutic applications across a host of diseases, such as pulmonary tuberculosis, tuberculous pericarditis, sepsis, lung cancer, and more. This article summarizes a large body of work published in the past five decades, describing various aspects of Mw and its potential for further therapeutic development. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index