Vaping causes an acute BMI‐dependent change in pulmonary blood flow.

Autor: Burrowes, K. S., Seal, M., Noorababaee, L., Pontré, B., Dubowitz, D., Sá, R. C., Prisk, G. K.
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Zdroj: Physiological Reports; Oct2024, Vol. 12 Issue 20, p1-14, 14p
Abstrakt: Vaping use has skyrocketed especially among young adults, however there is no consensus on how vaping impacts the lungs. We aimed to determine whether there were changes in lung function acutely after a standard vaping session or if there were differences in lung function metrics between a healthy never‐vaping cohort (N = 6; 27.3 ± 3.0 years) and a young asymptomatic vaping cohort (N = 14; 26.4 ± 8.0 years) indicating chronic changes. Pulmonary function measurements and impulse oscillometry were obtained on all participants. Oxygen‐enhanced and Arterial Spin Labelling MRI were used to measure specific ventilation and perfusion, respectively, before and after vaping, and in the control cohort at baseline. MRI metrics did not show any significant differences in specific ventilation or perfusion after vaping. Heart rate increased post‐vaping (68.1 ± 10.5 to 71.3 ± 8.7, p = 0.020); however, this and other metrics did not show a nicotine dose‐dependent effect. There was a significant negative correlation between BMI and change in mean perfusion post‐vaping (p = 0.003); those with normal/low BMI showing an increase in perfusion and vice versa for high BMI. This may be due to subjects lying supine during vaping inhalation. Pulmonary function metrics indicative of airways resistance showed significant differences between the vaping and control cohorts indicating early airway changes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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