The silent predictors: exploring galectin-3 and Irisin's tale in severe COVID-19.

Autor:	Nikolic, Valentina N., Popadic, Višeslav, Jankovic, Slobodan M., Govedarović, Nenad, Vujić, Stevan, Andjelković, Jelica, Stosic, Lazar S., Stevanović, Nikola Č., Zdravkovic, Marija, Todorovic, Zoran
Předmět:	COVID-19 ADULT respiratory distress syndrome IRISIN GALECTINS CRITICAL care medicine
Zdroj:	BMC Research Notes; 10/28/2024, Vol. 17 Issue 1, p1-6, 6p
Abstrakt:	Objective: This study aimed to evaluate the roles of galectin-3 and irisin as biomarkers in predicting severe outcomes in COVID-19 patients. Results: We analyzed serum levels of galectin-3 and irisin in 59 patients with severe COVID-19 and 30 healthy controls. Elevated galectin-3 levels were associated with increased risks of mortality, need for intensive care, and severe acute respiratory distress syndrome. The optimal cut-off value for galectin-3 was 13.47 ng/ml, with a sensitivity of 72.7% and specificity of 76.6%. Irisin levels did not differ significantly between survivors and non-survivors at admission or on the 3rd day post-admission, but approached significance on the 7th day. These findings suggest that galectin-3 could be a valuable prognostic biomarker for severe COVID-19 outcomes, while irisin's role remains to be clarified in further studies. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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