| Autor: |
Dattaray, Debolina, Roy, Payal, L., Raja, Chakraborty, Jui, Mandal, Tapan Kumar |
| Předmět: |
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| Zdroj: |
Exploratory Animal & Medical Research; Jun2024, Vol. 14 Issue 1, p68-75, 8p |
| Abstrakt: |
A study was undertaken to evaluate the skin sensitization and acute dermal irritation of Mesoporous antibacterial bioactive glass microsphere impregnated non-woven surgical cotton gauze (MABGmscg) dressings on shaved rabbits and guinea pigs. This study complied with guidelines 404 and 406 of the Organization for Economic Co-operation and Development (OECD). In the dermal irritation test, three different MABGmscg dressings were applied to the shaved skin of rabbits at three separate sites for four hours. The results demonstrated that the dressings did not cause unfavorable reactions, such as inflammation, erythema, or edema, on the unbroken skin of rabbits. As a result, MABGmscg dressing material was considered practically non-irritating based on its rating of primary irritation index. In the case of the Buehler test, three different doses of the MABG (mscg dressing) were used to initially sensitize the guinea pigs. They were later challenged at different sites with patches applied for 24 hours. The MABG dressing patches did not trigger any skin reactions when tested with various doses of the MABG (mscg dressing). These findings collectively indicate that the MABGmscg dressing did not induce any skin irritation or sensitization upon direct skin application in laboratory animals. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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