| Autor: |
Alexandru, Isaic, Davidescu, Lavinia, Motofelea, Alexandru Cătălin, Ciocarlie, Tudor, Motofelea, Nadica, Costachescu, Dan, Marc, Monica Steluta, Suppini, Noemi, Șovrea, Alina Simona, Coșeriu, Răzvan-Lucian, Bondor, Daniela-Andreea, Bobeică, Laura-Gabriela, Crintea, Andreea |
| Zdroj: |
International Journal of Molecular Sciences; Oct2024, Vol. 25 Issue 20, p11235, 19p |
| Abstrakt: |
Lung cancer, the leading cause of cancer-related deaths worldwide, is characterized by its aggressive nature and poor prognosis. As traditional chemotherapy has the disadvantage of non-specificity, nanomedicine offers innovative approaches for targeted therapy, particularly through the development of nanoparticles that can deliver therapeutic agents directly to cancer cells, minimizing systemic toxicity and enhancing treatment efficacy. VEGF and VEGFR are shown to be responsible for activating different signaling cascades, which will ultimately enhance tumor development, angiogenesis, and metastasis. By inhibiting VEGF and VEGFR signaling pathways, these nanotherapeutics can effectively disrupt tumor angiogenesis and proliferation. This review highlights recent advancements in nanoparticle design, including lipid-based, polymeric, and inorganic nanoparticles, and their clinical implications in improving lung cancer outcomes, exploring the role of nanomedicine in lung cancer diagnoses and treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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