Functional Properties and Components of Koenigia alpina Extract.

Autor: Lee, Kwan‐Woo, Mun, Su‐Hyun, Kim, Yeon‐A, Kim, Hyo‐Rim, Jin, Qinglong, Lee, Min‐Ki, Park, Soo Nam
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Zdroj: Skin Research & Technology; Oct2024, Vol. 30 Issue 10, p1-14, 14p
Abstrakt: Background: Koenigia alpina (All.) T.M.Schust. & Reveal (alpine knotweed) is a perennial herb belonging to the Polygonaceae family. Several studies have examined Polygonaceae species' potential applications as cosmeceutical materials; however, the potential of K. alpina as a cosmeceutical has not yet been studied. Materials and Methods: Hydrogen peroxide (H2O2) and lipopolysaccharide were used to induce an inflammatory response in RAW 264.7 cells. 2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH) radicals and H2O2 were used to evaluate the free‐radical scavenging activity of K. alpina extract and its protective effect against reactive oxygen species (ROS)‐induced cell damage. The whitening, antiaging, and cell proliferation/migration effects of the extracts were evaluated via tyrosinase inhibition, collagenase/elastase inhibition, and wound healing assays, respectively. The anti‐inflammatory effect was confirmed by evaluating nitric oxide (NO) production in RAW 264.7 cells. High‐performance liquid chromatography (HPLC), UV, and MS/MS were used to determine the main components of the extract and fractions. Results: The ethyl acetate (EA) fraction and its aglycone fraction showed very high free‐radical scavenging activities (47.5 and 47.1 µg/mL, respectively). The extract/fractions also showed significant tyrosinase inhibition (IC50 = 0.38 mg/mL in EA fraction), collagenase inhibition (IC50 = 0.21 mg/mL in EA fraction), and elastase inhibition (IC50 = 0.57 mg/mL in aglycone fraction). NO production in lipopolysaccharide‐induced RAW 264.7 cells was inhibited by the extract/fractions. The extract also promoted the closure of scratch wounds in HaCaT cells. The K. alpina extract/fractions contained cardamonin, quercetin, and quercitrin. Conclusion: K. alpina extracts/fractions showed antioxidant, antiaging, whitening, and anti‐inflammatory activities, suggesting they may have potential as antiaging cosmeceuticals. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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