Biallelic Loss of 7q34 (TRB) and 9p21.3 (CDKN2A / 2B) in Adult Ph-Negative Acute T-Lymphoblastic Leukemia.

Autor: Risinskaya, Natalya, Abdulpatakhov, Abdulpatakh, Chabaeva, Yulia, Aleshina, Olga, Gladysheva, Maria, Nikulina, Elena, Bolshakov, Ivan, Yushkova, Anna, Dubova, Olga, Vasileva, Anastasia, Obukhova, Tatiana, Julhakyan, Hunan, Kapranov, Nikolay, Galtseva, Irina, Kulikov, Sergey, Sudarikov, Andrey, Parovichnikova, Elena
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Zdroj: International Journal of Molecular Sciences; Oct2024, Vol. 25 Issue 19, p10482, 11p
Abstrakt: Tumor cells of acute lymphoblastic leukemia (ALL) may have various genetic abnormalities. Some of them lead to a complete loss of certain genes. Our aim was to reveal biallelic deletions of genes in Ph–negative T-ALL. Chromosomal microarray analysis (CMA) was performed for 47 patients with de novo Ph–negative T-ALL, who received treatment according to RALL-2016m clinical protocol at the National Medical Research Center for Hematology (Moscow, Russia) from 2017 to 2023. Out of forty-seven patients, only three had normal molecular karyotype. The other 44 patients had multiple gains, losses, and copy neutral losses of heterozygosity. Biallelic losses were found in 14 patients (30%). In ten patients (21%), a biallelic deletion of 9p21.3 involved a different number of genes, however CDKN2A gene loss was noted in all ten cases. For seven patients (15%), a biallelic deletion of 7q34 was found, including two genes—PRSS1, PRSS2 located within the T-cell receptor beta (TRB) locus. A clonal rearrangement of the TRB gene was revealed in 6 out of 7 cases with 7q34 biallelic loss. Both biallelic deletions can be considered favorable prognostic factors, with an association with 9p21 being statistically significant (p = 0.01) and a trend for 7q34 (p = 0.12) being observed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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