| Abstrakt: |
Aim: In the current study, serum levels of endocan in patients attended with ST-elevation myocardial infarction, as well as the possible correlation with apolipoprotein-A1 (APO-A1) and APO-B were investigated. Materials & methods: In 80 men, endocan, cTnI, APO-A1, and APO-B levels were measured. Finally, the correlation of endocan with APO-A1, APO-B, and APO-B/ APO-A1 ratio was assessed. Results: Significant changes in APO-A1, APO-B, endocan levels, and APO-B/APO-A1 ratio were found in acute myocardial infarction cases compared with the control arm (p < 0.05). In addition, our finding showed a significant correlation between APO-B and endocan levels, but not APO-A. Conclusion: High endocan level is an independent indicator of endothelial dysfunction and ischemic cardiovascular conditions, which could be related to APO-B. Article highlights Background Myocardial infarction is a leading cause of human death in the clinical setting. Several studies have been performed to detect valid and accurate biomarkers for monitoring the occurrence and intensity of ischemic changes in individuals with infarction. Methods A relationship between serum endocan level and apolipoproteins (APO-A1 and APO-B) was studied in ST-elevation myocardial infarction patients. Results Significant dynamic changes were detected in APO-A1, APO-B, cTnI, and endocan levels in acute myocardial infarction patients when compared with healthy subjects. The cTnI, APO-B, endocan levels, and APO-B/APO-A1 ratio were significantly increased in acute myocardial infarction individuals. Conclusion There is a close relationship between the serum endocan and APO levels in acute myocardial infarction patients. [ABSTRACT FROM AUTHOR] |
