| Abstrakt: |
A recent study conducted by researchers at Chongqing Medical University in China has found that zinc-alpha2-glycoprotein (ZAG) plays a role in regulating blood pressure and urinary sodium excretion in individuals with hypertension. The study found that serum ZAG levels were significantly decreased in hypertensive participants and were associated with impaired urinary sodium excretion. The researchers also discovered that Azgp1(-/-) mice, which lack the Azgp1 gene responsible for producing ZAG, exhibited increased blood pressure and impaired urinary sodium excretion. However, when the mice were treated with a recombinant ZAG protein, their blood pressure and urinary sodium excretion improved. These findings suggest that ZAG may be a potential target for kidney-focused therapies in the prevention and treatment of hypertension. [Extracted from the article] |
