| Autor: |
Ali, Mohammad, Longet, Stephanie, Neale, Isabel, Rongkard, Patpong, Chowdhury, Forhad Uddin Hassan, Hill, Jennifer, Brown, Anthony, Laidlaw, Stephen, Tipton, Tom, Hoque, Ashraful, Hassan, Nazia, Hackstein, Carl-Philipp, Adele, Sandra, Akther, Hossain Delowar, Abraham, Priyanka, Paul, Shrebash, Rahman, Md Matiur, Alam, Md Masum, Parvin, Shamima, Mollah, Forhadul Hoque |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Oct2024, Vol. 218 Issue 1, p78-92, 15p |
| Abstrakt: |
Objective: Obesity and type 2 diabetes (DM) are risk factors for severe coronavirus disease 2019 (COVID-19) outcomes, which disproportionately affect South Asian populations. This study aims to investigate the humoral and cellular immune responses to SARS-CoV-2 in adult COVID-19 survivors with overweight/obesity (Ov/Ob, BMI ≥ 23 kg/m2) and DM in Bangladesh. Methods: In this cross-sectional study, SARS-CoV-2-specific antibody and T-cell responses were investigated in 63 healthy and 75 PCR-confirmed COVID-19 recovered individuals in Bangladesh, during the pre-vaccination first wave of the COVID-19 pandemic in 2020. Results: In COVID-19 survivors, SARS-CoV-2 infection induced robust antibody and T-cell responses, which correlated with disease severity. After adjusting for age, sex, DM status, disease severity, and time since onset of symptoms, Ov/Ob was associated with decreased neutralizing antibody titers, and increased SARS-CoV-2 spike-specific IFN-γ response along with increased proliferation and IL-2 production by CD8 + T cells. In contrast, DM was not associated with SARS-CoV-2-specific antibody and T-cell responses after adjustment for obesity and other confounders. Conclusion: Ov/Ob is associated with lower neutralizing antibody levels and higher T-cell responses to SARS-CoV-2 post-COVID-19 recovery, while antibody or T-cell responses remain unaltered in DM. Despite similar IgG antibody levels, adults with overweight/obesity (BMI ≥ 23 kg/m2) have lower neutralizing antibody capacity and higher T-cell responses to SARS-CoV-2 following COVID-19 recovery. In contrast, antigen-specific antibody and T-cell responses are preserved in individuals with diabetes mellitus who survive SARS-CoV-2 infection. Graphical Abstract [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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