| Autor: |
Ranjbar, Maral, Whetstone, Christiane E., Cusack, Ruth P., Al‐Sajee, Dhuha, Omer, Hafsa, Alsaji, Nadia, Ho, Terence, Duong, MyLinh, Mitchell, Patrick, Satia, Imran, Keith, Paul K., Xie, Yanqing, MacLean, Jonathan, Sommer, Doron D., O'Byrne, Paul M., Sehmi, Roma, Gauvreau, Gail M. |
| Předmět: |
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| Zdroj: |
Allergy; Oct2024, Vol. 79 Issue 10, p2856-2858, 3p |
| Abstrakt: |
This article compares the expression of SARS-CoV-2 receptors in the upper and lower airways of individuals with allergic asthma. The study found that the receptors ACE2 and TMPRSS2 were more abundant in the bronchial tissue of allergic asthmatics compared to healthy controls and nasal tissue of individuals with allergic rhinitis. Additionally, the levels of alarmin cytokines IL-33 and TSLP were higher in the bronchial tissue of allergic asthmatics. These findings suggest that individuals with allergic airway disease may have a higher number of viral entry receptors in their airways. However, despite these findings, asthmatic patients have been shown to have a lower risk of COVID-19 infection, which may be influenced by various factors. Further research is needed to fully understand the mechanisms underlying this lower risk and its implications for COVID-19 management in individuals with allergic airway disease. [Extracted from the article] |
| Databáze: |
Complementary Index |
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