| Autor: |
DiMarco, Kaitlyn G., Chapman, Christopher L., Weiser, Natasha E., Matsell, Emma R., Lucernoni, Kathryn M., Chacon, Samantha, Grivette, Margaret M. B., Halliwill, John R., Lovering, Andrew T., Minson, Christopher T. |
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| Zdroj: |
Experimental Physiology; Oct2024, Vol. 109 Issue 10, p1782-1795, 14p |
| Abstrakt: |
The use of acute carbon monoxide inhalation (COi) and hot water immersion (HWI) are of growing interest as interventions to stimulate erythropoietin (EPO) production. However, whether EPO production is further augmented when combining these stressors and whether there are sex differences in this response are poorly understood. Therefore, we measured circulating EPO concentration in response to acute COi and HWI independently and in combination and determined whether the responses were altered by sex. Participants completed three study visits—COi, HWI, and combined COi and HWI—separated by 1 week in a randomized, balanced, crossover design. Renal blood velocity was measured during all interventions, and carboxyhaemoglobin was measured during and after COi. Serum samples were analysed every hour for 6 h post‐intervention for EPO concentration. HWI decreased renal blood velocity (46.2 cm/s to 36.2 cm/s) (P < 0.0001), and COi increased carboxyhaemoglobin (1.5%–12.8%) (P < 0.0001) without changing renal blood velocity (46.4–45.2 cm/s) (P = 0.4456). All three interventions increased peak EPO concentration from baseline (COi: 6.02–9.74 mIU/mL; HWI: 6.80–11.10 mIU/mL; COi + HWI: 6.71–10.91 mIU/mL) (P = 0.0048) and to the same extent (P = 0.3505). On average, females increased EPO while males did not in response to COi (females: 6.17 mIU/mL; males: 1.27 mIU/mL) (P = 0.0010), HWI (females: 6.47 mIU/mL; males: 2.14 mIU/mL) (P = 0.0104), and COi and HWI (females: 6.65 mIU/mL; males: 1.76 mIU/mL) (P = 0.0256). These data emphasize that combining these interventions does not augment EPO secretion and that these interventions may work better in females. What is the central question of the study?Do acute heat stress and carbon monoxide inhalation alone and in combination increase erythropoietin, and are there sex differences in erythropoietin?What is the main finding and its importance?All interventions increased erythropoietin, but combining the two interventions did not further augment erythropoietin. While erythropoietin increased in females in response to all interventions, there was greater erythropoietin variability in males and therefore, on average, males did not increase erythropoietin. This suggests that combining heat and hypoxic stressors does not further augment erythropoietin concentrations but these interventions may have greater efficacy in females. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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