Low-dose glucocorticoid increase the risk of fracture in postmenopausal women with low bone mass: a retrospective cohort study.

Autor:	Park, So Young, Ahn, Seong Hee, Bae, Gi Hwan, Jang, Sunmee, Kwak, Mi Kyung, Kim, Ha Young, Kim, Se Hwa
Předmět:	RISK assessment WOMEN BONE density VERTEBRAL fractures POSTMENOPAUSE TREATMENT effectiveness RETROSPECTIVE studies ORAL drug administration DESCRIPTIVE statistics BONE fractures MEDICAL records ACQUISITION of data OSTEOPOROSIS COMPARATIVE studies CONFIDENCE intervals GLUCOCORTICOIDS PATIENT aftercare DISEASE risk factors
Zdroj:	Osteoporosis International; Oct2024, Vol. 35 Issue 10, p1779-1787, 9p
Abstrakt:	Summary: Long-term glucocorticoids (GCs) treatment is associated with osteoporosis and fractures. We investigated whether low-dose GC treatment also increased the risk of osteoporotic fractures, and the results showed that even low-dose GC treatment increased the risk of osteoporotic fractures, especially spine fractures. Purpose: The effect of low-dose glucocorticoid (GC) therapy on the fracture risk in postmenopausal women with low bone mass was investigated. Methods: 119,790 66-year-old postmenopausal women with low bone mass based on bone mineral density (BMD) results were included. GC group consisted of patients who had been prescribed oral GCs within 6 months of BMD testing. In GC group, GCs dosage was calculated by a defined daily dose (DDD), and divided into five groups according to GC usage (Group 1[G1]; < 11.25 DDDs, G2; ≥ 11.25, < 22.5 DDDs, G3; ≥ 22.5, < 45 DDDs, G4; ≥ 45, < 90 DDDs, G5; ≥ 90 DDDs). The risk of major osteoporotic fractures (MOF) and non-MOF was analyzed and compared with that of the control group during the 1-year follow-up. Results: The risk of total fracture was higher in G3–G5 than in the control group (G3, hazard ratio (HR) 1.25, 95% confidence interval [CI] 1.07–1.46; G4, 1.37 [1.13–1.66]; G5 1.45 [1.08–1.94]). The risk of MOF was higher in all groups except G2 than in the control group (G1, 1.23 [1.05–1.45]; G3, 1.37 [1.11–1.68]; G4, 1.41 [1.09–1.83]; G5, 1.66 [1.14–2.42]). The risk of spine fracture was significantly higher in all GC groups except G2 than in the control group. The risk of non-MOF was higher only in G4 than in the control group (G4, 1.48 [1.13–1.94]). Conclusion: Low-dose GC therapy can increase the risk of osteoporotic fractures, particularly spine fractures, in postmenopausal women with low bone mass. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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