The discovery and development of GLP-1 based drugs that have revolutionized the treatment of obesity.

Autor: Friedman, Jeffrey M.
Předmět:
Zdroj: Proceedings of the National Academy of Sciences of the United States of America; 9/24/2024, Vol. 121 Issue 39, p1-5, 5p
Abstrakt: The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her role in developing sustained acting versions of this hormone as a treatment for obesity. Each of the three had a distinct set of skills that made this advance possible; Habener is an endocrinologist and molecular biologist, Mojsov is a peptide chemist, and Knudsen is a pharmaceutical scientist. Their collective efforts have done what few thought possible--the development of highly effective medicines for reducing weight. Their research has also solved a mystery that began more than a century ago. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index