Encephalitis associated with antim-GluR5 antibodies.
| Autor: | Alves Pedrosa, Denison, Fregadolli Ferreira, João Henrique, Gleizer, Rene, Carra, Rafael Bernhart, de Carvalho, Rachel Marin, Endmayr, Verena, Hoftberger, Romana, Almeida Dutra, Lívia |
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| Předmět: |
ENCEPHALITIS diagnosis
CEREBROSPINAL fluid examination INTRAVENOUS immunoglobulins THYROID gland function tests AUTOANTIBODIES NYSTAGMUS VITAMIN B12 FLUORESCENT antibody technique HALLUCINATIONS MUSCLE strength BLOOD sugar OPHTHALMOSCOPY METHYLPREDNISOLONE HODGKIN'S disease MUTISM LIVER function tests |
| Zdroj: | Practical Neurology; Aug2024, Vol. 24 Issue 4, p306-309, 4p |
| Abstrakt: | A 30-year-old woman had 5 days of visual hallucinations, nystagmus, memory impairment and mutism. On examination, she was disorientated with reduced attention span, gazeevoked nystagmus, paratonia and abnormal frontal reflexes. Cerebrospinal fluid (CSF) showed 80 cells, protein 0.41 g/L and glucose 3.2 mmol/L (plasma glucose 5.0 mmol/L). MR scan of the brain showed involvement of limbic and extra-limbic regions and brainstem. Commercial cell-based assays were negative, but tissue-based assays showed neuropil staining, and cell-based assays for anti-metabotropic glutamate receptor 5 (mGluR5) antibodies were positive in serum and CSF. Six months later, she was diagnosed with Hodgkin's lymphoma. This case emphasises the broader clinical spectrum of anti-mGluR5 encephalitis, challenging its initial characterisation as Ophelia syndrome. It underscores the significance of interpreting commercial cell- based assays and advocates for tissue-based assay testing followed by cell-based assay testing in serum and CSF for diagnosing rare autoimmune encephalitis. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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