| Autor: |
Shah, Sonali S, Libianto, Renata, Gwini, Stella May, Russell, Grant, Young, Morag J, Fuller, Peter J, Yang, Jun |
| Předmět: |
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| Zdroj: |
Journal of the Endocrine Society; Oct2024, Vol. 8 Issue 10, p1-2, 2p |
| Abstrakt: |
This article discusses the prevalence and characteristics of low-renin hypertension in a primary care population. It states that approximately 1 in 4 people with hypertension have low renin, but most do not meet the criteria for primary aldosteronism or have a monogenetic cause. The study found that people with low-renin hypertension with no apparent cause are more likely to be older, female, and have lower aldosterone concentration. The article also mentions the term "Liddle-like syndrome" used by Professor Spence to refer to the high prevalence of the low renin/low aldosterone phenotype in other cohorts. It emphasizes that low-renin "essential" hypertension encompasses several disease processes and potential underlying causes. The study did not explore optimal management for this cohort but suggests that mineralocorticoid receptor antagonists may be a reasonable first-line option. The article acknowledges the possible role of gene polymorphisms in those with low-renin/aldosterone phenotype but notes that more research is needed to accurately characterize the pathophysiology of low-renin hypertension in larger and more diverse populations. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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