| Autor: |
Alhummiany, Bashair, Sharma, Kanishka, Buckley, David L., Soe, Kywe Kywe, Sourbron, Steven P. |
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| Zdroj: |
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine; Aug2024, Vol. 37 Issue 4, p565-582, 18p |
| Abstrakt: |
Objectives: Renal blood flow (RBF) is controlled by a number of physiological factors that can contribute to the variability of its measurement. The purpose of this review is to assess the changes in RBF in response to a wide range of physiological confounders and derive practical recommendations on patient preparation and interpretation of RBF measurements with MRI. Methods: A comprehensive search was conducted to include articles reporting on physiological variations of renal perfusion, blood and/or plasma flow in healthy humans. Results: A total of 24 potential confounders were identified from the literature search and categorized into non-modifiable and modifiable factors. The non-modifiable factors include variables related to the demographics of a population (e.g. age, sex, and race) which cannot be manipulated but should be considered when interpreting RBF values between subjects. The modifiable factors include different activities (e.g. food/fluid intake, exercise training and medication use) that can be standardized in the study design. For each of the modifiable factors, evidence-based recommendations are provided to control for them in an RBF-measurement. Conclusion: Future studies aiming to measure RBF are encouraged to follow a rigorous study design, that takes into account these recommendations for controlling the factors that can influence RBF results. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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