| Autor: |
Chalichem, Nehru Sai Suresh, Kandpal, J.B., Mahanta, Baidyanath, Khan, Mohammed S. |
| Předmět: |
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| Zdroj: |
Journal of Biologically Active Products from Nature; Aug2024, Vol. 14 Issue 4, p481-496, 16p |
| Abstrakt: |
Curcumin is well known for its diverse health benefits based on the traditional and current scientific evidence. The aim of the present study was to evaluate the safety of Maxicuma® made by using proprietary LIMAN technology that involves encapsulation of 40% curcuminoids with lipid matrix. The safety profile was studied with single dose and repeated dose oral administration of Maxicuma® in both rodents and non-rodents. The toxicity study was conducted at a range of 0.5 to 10 gm curcumin equivalent to human dose per day. None of the tested doses in any of the species produced treatment related clinical signs of toxicity with respect to haematology and blood chemistry parameters and mortality. Moreover gross and histopathological findings did not show any remarkable and treatment related changes. The treated animals exhibited normal weight gain and comparable feed intake. Based on the obtained results Maxicuma® up to 220 mg/kg oral dose could be considered as safe, tolerated and no observed adverse effect level (NOAEL) dose in rabbits. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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