Hepatic Involvement in Common Variable Immunodeficiency: a Single Center Experience.
| Autor: | EVCEN, Recep, ESEN, Haci Hasan, COLKESEN, Fatih, AYKAN, Filiz SADI, KILINC, Mehmet, ERGUN, Ummugulsum YILMAZ, AKKUS, Fatma Arzu, ONALAN, Tugba, GEREK, Selim KAHRAMAN Mehmet Emin, YILDIZ, Eray, KOKBUDAK, Naile, ARSLAN, Sevket |
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| Předmět: |
BIOPSY
T cells HEPATITIS SEX distribution COMMON variable immunodeficiency SYMPTOMS RETROSPECTIVE studies ALKALINE phosphatase SEVERITY of illness index LIVER diseases IMMUNOHISTOCHEMISTRY CHRONIC diseases ANTIGENS MEDICAL records ACQUISITION of data AUTOIMMUNE diseases COMPARATIVE studies CD4 antigen LIVER function tests DISEASE incidence SPLEEN diseases B cells |
| Zdroj: | Asthma Allergy Immunology / Astim Allerji Immunoloji; Aug2024, Vol. 22 Issue 2, p130-137, 8p |
| Abstrakt: | Objective: Common Variable Immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency in adults. This study evaluates the clinical, immune, and immunohistological characteristics of hepatic involvement in CVID. Materials and Methods: Medical records of 72 CVID patients, including 7 with liver biopsies, were retrospectively reviewed. Immunohistochemical staining was performed to identify immune cell infiltration. Results: We enrolled 72 patients with a median age of 38 (22--77) years, and 47% (n = 34) were female. Elevated alkaline phosphatase (ALP) levels were found in 58.3% (n=42) of the patients. Hepatic involvement was more prevalent among females, and those with hepatic involvement displayed a higher incidence of autoimmune disease. Splenomegaly was identified in 85% of the patients with hepatic involvement. Notably, switched memory B cells (IgD- CD19+ CD27+) and the CD4+/CD8+ ratio were statistically lower in patients with hepatic involvement (p=0.031, p=0.047). Liver biopsies were performed on 7 patients, revealing minimal to severe chronic hepatitis. Immunohistologic analysis of these liver biopsies revealed varying degrees of positivity of CD8+, CD4+, and CD16+. However, staining for CD21, CD56, and CD138 yielded negative results. Conclusion: Our findings suggest that immune cells, particularly CD8+, CD4+, and CD16+ cells, may play a role in developing hepatic involvement. Understanding the underlying causes and mechanisms of hepatic involvement in CVID patients can lead to early diagnosis and targeted treatments, ultimately improving the prognosis. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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