| Autor: |
Nishimura, Kazuki, Takahara, Kiyoshi, Komura, Kazumasa, Ishida, Mitsuaki, Hirosuna, Kensuke, Maenosono, Ryoichi, Ajiro, Masahiko, Sakamoto, Moritoshi, Iwatsuki, Kengo, Nakajima, Yuki, Tsujino, Takuya, Taniguchi, Kohei, Tanaka, Tomohito, Inamoto, Teruo, Hirose, Yoshinobu, Ono, Fumihito, Kondo, Yoichi, Yoshimi, Akihide, Azuma, Haruhito |
| Předmět: |
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| Zdroj: |
NPJ Precision Oncology; 9/17/2024, Vol. 8 Issue 1, p1-8, 8p |
| Abstrakt: |
Hyper progressive disease (HPD) is a paradoxical phenomenon characterized by accelerated tumor growth following treatment with immune checkpoint inhibitors. However, the pathogenic causality and its predictor remain unknown. We herein report a fatal case of HPD in a 50-year-old man with metastatic bladder cancer. He had achieved a complete response (CR) through chemoradiation therapy followed by twelve cycles of chemotherapy, maintaining CR for 24 months. Three weeks after initiating maintenance use of a PD-L1 inhibitor, avelumab, a massive amount of metastases developed, leading to the patient's demise. Omics analysis, utilizing metastatic tissues obtained from an immediate autopsy, implied the contribution of M2 macrophages, TGF-β signaling, and interleukin-8 to HPD pathogenesis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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