| Autor: |
Zhou, Dong Ju, Liu, Wei Ming, Dai, Su Ping, Jiang, Shuai Qiang, Wang, Yin, Yang, Jia Jia, Chen, Ya Wei, Chen, Jun Liang, Park, Hyun Jin, Zhou, Hui Yun |
| Předmět: |
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| Zdroj: |
New Journal of Chemistry; 9/28/2024, Vol. 48 Issue 36, p15884-15893, 10p |
| Abstrakt: |
In our work, serine-modified β-cyclodextrin (Ser-β-CD) was synthesized and a berberine hydrochloride (BBH)/Ser-β-CD inclusion complex (IC) was prepared using the freeze-drying method. Phase solubility studies showed that BBH and Ser-β-CD formed stable inclusion complexes in a stoichiometric ratio of 1 : 1. The IC was characterized using SEM and FT-IR analyses. The results of molecular docking showed that BBH was completely contained in the Ser-β-CD cavity and the binding energy was −7.87 kcal mol−1. The results of in vitro release studies indicated that BBH could be released slowly from the IC. In addition, the prepared Ser-β-CD and IC had good biocompatibility. The IC demonstrated excellent antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Therefore, the BBH/Ser-β-CD IC has potential application prospects in biomedicine and food industry. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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