| Autor: |
Savoye, Emilie, Santin, Gaëlle, Legeai, Camille, Kerbaul, François, Gaillard, François, Pastural, Myriam |
| Předmět: |
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| Zdroj: |
Transplant International; 2024, p1-12, 12p |
| Abstrakt: |
Living donation (LD) transplantation is the preferred treatment for kidney failure as compared to donation after brain death (DBD), but age may play a role. We compared the 1-year estimated glomerular filtration rate (eGFR) after kidney transplantation for recipients of LD and DBD stratified by recipient and donor age between 2015 and 2018 in a matched cohort. The strength of the association between donation type and 1-year eGFR differed by recipient age (Pinteraction < 0.0001). For LD recipients aged 40-54 years versus same-aged DBD recipients, the adjusted odds ratio (aOR) for eGFR =60 mL/min/1.73 m2 was 1.48 (95% CI: 1.16-1.90). For DBD recipients aged = 60 years, the aOR was 0.18 (95% CI: 0.12-0.29) versus DBD recipients aged 40-54 years but was 0.91 (95% CI: 0.67-1.24) versus LD recipients aged =60 years. In the matched cohort, 4-year graft and patient survival differed by donor age and type. As compared with DBD grafts, LD grafts increased the proportion of recipients with 1-year eGFR =60 mL/min/1.73 m2. Recipients aged =60 years benefited most from LD transplantation, even if the donor was aged =60 years. For younger recipients, large age differences between donor and recipient could also be addressed with a paired exchange program. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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