| Abstrakt: |
A recent study conducted by researchers at Southwest Medical University in Sichuan, China, aimed to develop a novel antidepressant with high activity. The study evaluated eight novel curcumin analogues in vitro for their antidepressant efficacy. Among them, CACN136 showed the strongest antidepressant effect, demonstrating antioxidant and protective effects on cells damaged by glutamate and oxidative stress. In vivo experiments on mice confirmed the antidepressant properties of CACN136, which were linked to a decrease in the metabolism of 5-HT and the modulation of oxidative stress levels. The researchers concluded that CACN136 has the potential to treat depression and could be an effective antidepressant. [Extracted from the article] |
