| Autor: |
Harrer, Caroline E, Mayer, Leonie, Fathi, Anahita, Lassen, Susan, Ly, My L, Zinser, Madeleine E, Wolf, Timo, Becker, Stephan, Sutter, Gerd, Dahlke, Christine, Addo, Marylyn M, Group, for the MVA-MERS-S Study |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 8/15/2024, Vol. 230 Issue 2, pe327-e332, 6p |
| Abstrakt: |
Licensed vaccines against the Middle East respiratory syndrome coronavirus (MERS-CoV), an emerging pathogen of concern, are lacking. The modified vaccinia virus Ankara vector-based vaccine MVA-MERS-S, expressing the MERS-CoV-spike glycoprotein (MERS-S), is one of 3 candidate vaccines in clinical development and elicits robust humoral and cellular immunity. Here, we identified for the first time a MERS-S–specific CD8+ T-cell epitope in an HLA-A*03:01/HLA-B*35:01-positive vaccinee using a screening assay, intracellular cytokine staining, and in silico epitope prediction. As evidence from MERS-CoV infection suggests a protective role of long-lasting CD8+ T-cell responses, the identification of epitopes will facilitate longitudinal analyses of vaccine-induced T-cell immunity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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