The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo.

Autor: Rhodin, Michael H. J., Reyes, Archie C., Balakrishnan, Anand, Bisht, Nalini, Kelly, Nicole M., Gibbons, Joyce Sweeney, Lloyd, Jonathan, Vaine, Michael, Cressey, Tessa, Crepeau, Miranda, Shen, Ruichao, Manalo, Nathan, Castillo, Jonathan, Levene, Rachel E., Leonard, Daniel, Zang, Tianzhu, Jiang, Lijuan, Daniels, Kellye, Cox, Robert M., Lieber, Carolin M.
Zdroj: Nature Communications; 8/1/2024, Vol. 15 Issue 1, p1-12, 12p
Abstrakt: The COVID-19 pandemic has led to the deaths of millions of people and severe global economic impacts. Small molecule therapeutics have played an important role in the fight against SARS-CoV-2, the virus responsible for COVID-19, but their efficacy has been limited in scope and availability, with many people unable to access their benefits, and better options are needed. EDP-235 is specifically designed to inhibit the SARS-CoV-2 3CLpro, with potent nanomolar activity against all SARS-CoV-2 variants to date, as well as clinically relevant human and zoonotic coronaviruses. EDP-235 maintains potency against variants bearing mutations associated with nirmatrelvir resistance. Additionally, EDP-235 demonstrates a ≥ 500-fold selectivity index against multiple host proteases. In a male Syrian hamster model of COVID-19, EDP-235 suppresses SARS-CoV-2 replication and viral-induced hamster lung pathology. In a female ferret model, EDP-235 inhibits production of SARS-CoV-2 infectious virus and RNA at multiple anatomical sites. Furthermore, SARS-CoV-2 contact transmission does not occur when naïve ferrets are co-housed with infected, EDP-235-treated ferrets. Collectively, these results demonstrate that EDP-235 is a broad-spectrum coronavirus inhibitor with efficacy in animal models of primary infection and transmission.In this study, the authors report the small molecule inhibitor EDP-235 as a potent inhibitor of SARS-CoV-2 and show that it is effective against a range of variants and other coronaviruses and that it suppresses virus replication, reduces lung damage, and prevents transmission in small animal models. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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