| Autor: |
Dong Hwa Oh, Julia, Lu Freem, Saunders, Dillan D. Z., McTeir, Lynn, Gilhooley, Hazel, Jackson, Melany, Glover, James D., Smith, Jonathan, Schoenebeck, Jeffrey J., Lettice, Laura A., Sang, Helen M., Davey, Megan G. |
| Předmět: |
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| Zdroj: |
Development (09501991); Jul2024, Vol. 151 Issue 14, p1-13, 13p |
| Abstrakt: |
The cellular and genetic networks that contribute to the development of the zeugopod (radius and ulna of the forearm, tibia and fibula of the leg) are not well understood, although these bones are susceptible to loss in congenital human syndromes and to the action of teratogens such as thalidomide. Using a new fate-mapping approach with the Chameleon transgenic chicken line, we show that there is a small contribution of SHH-expressing cells to the posterior ulna, posterior carpals and digit 3. We establish that although the majority of the ulna develops in response to paracrine SHH signalling in both the chicken and mouse, there are differences in the contribution of SHHexpressing cells between mouse and chicken as well as between the chicken ulna and fibula. This is evidence that, although zeugopod bones are clearly homologous according to the fossil record, the gene regulatory networks that contribute to their development and evolution are not fixed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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