| Autor: |
Carvalho, Luana Cristina Faria, Ferreira, Flávia Monteiro, Dias, Bruna Vidal, Azevedo, Daniela Couto de, de Souza, Gustavo Henrique Bianco, Milagre, Matheus Marque, de Lana, Marta, Vieira, Paula Melo de Abreu, Carneiro, Cláudia Martins, Paula-Gomes, Sílvia de, Cangussu, Silvia Dantas, Costa, Daniela Caldeira |
| Předmět: |
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| Zdroj: |
Archives of Physiology & Biochemistry; Aug2024, Vol. 130 Issue 4, p460-474, 15p |
| Abstrakt: |
The role of silymarin in hepatic lipid dysfunction and its possible mechanisms of action were investigated. To evaluate the effects of silymarin on hepatic and metabolic profiles in mice fed with 30% fructose for 8 weeks. We evaluated the antioxidant profile of silymarin; mice consumed 30% fructose and were treated with silymarin (120 mg/kg/day or 240 mg/kg/day). We performed biochemical, redox status, and histopathological assays. RT-qPCR was performed to detect ACC-1, ACC-2, FAS, and CS expression, and western blotting to detect PGC-1α levels. Silymarin contains high levels of phenolic compounds and flavonoids and exhibited significant antioxidant capacity in vitro. In vivo, the fructose-fed groups showed increased levels of AST, ALT, SOD/CAT, TBARS, hepatic TG, and cholesterol, as well as hypertriglyceridaemia, hypercholesterolaemia, and increased ACC-1 and FAS. Silymarin treatment reduced these parameters and increased mRNA levels and activity of hepatic citrate synthase. These results suggest that silymarin reduces worsening of NAFLD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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