| Autor: |
Wang, Xiuhua, Zhou, Jianrong Steve |
| Zdroj: |
SCIENCE CHINA Chemistry; Aug2024, Vol. 67 Issue 8, p2566-2570, 5p |
| Abstrakt: |
Asymmetric reductive amination directly converts ketones and amines to alkylamines, which are important motifs in medicines. We report that cationic nickel complexes of chiral diphosphines promote enantioselective reductive amination of benzylic ketones with both arylamines and benzhydrazide. Isopropanol was used as a safe and cheap source of hydrogen instead of formic acid. The reaction can be readily applied to a concise synthesis of diarylethylamines, a class of neuroactive substances. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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