| Autor: |
Wemimo, Rasheed Mumini, Eziagu, Uchechukwu Brian, Ayoade, Adekunle Adebayo, Idowu, Najeem Adedamola, Dawodu, Olayemi Olubunmi, Akande, Halimat, Ayinde, Abdulmajeed Abdulrafiu, Olayide, Agodirin, Fate, Aliyu, John, Obiajulu Fred, Ajanaku, Jimoh Abdulrazak, Ya'u, Nabila Ado, Enenche, Iyalla Simon |
| Předmět: |
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| Zdroj: |
Annals of Tropical Pathology; 2023, Vol. 14 Issue 2, p103-106, 4p |
| Abstrakt: |
Breast carcinoma with osteoclast-like stromal giant cells (OGCs) is a rare variant of invasive ductal carcinoma of no special type. (NST). The unique stromal features of this tumour can be found in some other invasive breast carcinoma such as papillary carcinoma. lobular carcinoma, and metaplastic carcinoma. The origin of OGC have been shown to be derived from macrophages and the tumour biology showed variable immunophenotyping and prognosis. Thus, we report a case of a 43-year-old woman who had a painless lump in her left breast that had grown larger over a period of 2 months. The lump had specific histopathological characteristics that were consistent with invasive ductal carcinoma of no special type (NST) with osteoclast-like giant cells (OGC), Nottingham grade 3 and its pathological stage was pT4N0Mx (clinical stage IVb). The tumour cells were not immunoreactive with human epidermal growth factor-2 (HER- 2), progesterone receptor (PR), and oestrogen receptor (ER) antibodies. She underwent a left breast mastectomy, followed by conventional chemotherapy and was tumour-free for two years. The left mastectomy defect was subsequently repaired using a transverse thoracoepigastric flap. A crucial factor in the patient's mortality was a recurrence that showed up at the patient's follow-up appointment after eight months, along with accompanying bleeding from the mass lesion site with associated severe anaemia. The prognosis is unpredictable in IBC with OGC and triplenegative molecular subtypes. Our case offers information about the patient's characteristics and case presentation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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