| Autor: |
Fernández, Rogelio, Pérez, Marta, Losada, Alejandro, Reboredo, Silvia, Gómez-San Juan, Asier, Martín, María Jesús, Francesch, Andrés, Munt, Simon, Cuevas, Carmen |
| Zdroj: |
Marine Drugs; Jul2024, Vol. 22 Issue 7, p303, 16p |
| Abstrakt: |
In our continuing search for biologically active new chemical entities from marine organisms, we have isolated a new cyclic depsipeptide, PM170453 (1), from a cyanobacterium of the genus Lyngbya sp., collected in the Indo-Pacific Ocean. Structure elucidation of the isolated compound was determined by spectroscopic methods including MS, 1H, 13C and 2D-NMR. To solve the supply problem for 1 and progress pharmaceutical development, the total synthesis of 1 that involves a total of 20 chemical steps in a convergent process was carried out. Its in vitro cytotoxic activity against four human tumor cell lines, as well as the inhibition of the interaction between the programmed cell death protein 1 PD-1 and its ligand PD-L1 were also evaluated. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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