| Autor: |
Butel-Simoes, Grace I., Bajaj, Nupur, Asad, Sultan, Moselen, Jean, Orlando, Nicole, Steinig, Eike, Tran, Thomas, Druce, Julian, Caly, Leon, Bishop, Emma, Harangozo, Chanad, Lim, Chuan Kok |
| Předmět: |
|
| Zdroj: |
Viruses (1999-4915); Jul2024, Vol. 16 Issue 7, p998, 6p |
| Abstrakt: |
Dengue neurological disease is an uncommon yet severe complication of dengue infection. It can manifest as encephalitis, encephalopathy, neuro-ophthalmic complications, or neuromuscular disorders. Severe infection can result in viral shedding across multiple body sites. We describe a case of severe neuro-ophthalmic dengue infection in an otherwise healthy returned traveller, presenting with prolonged multiple-body-site viral detections by PCR. The dengue virus (DENV) dynamics and serological response support a direct DENV neuropathogenicity. A retrospective review of the laboratory data at the Victorian Infectious Diseases Reference Laboratory (VIDRL) suggests that blood is the most frequent sample type with DENV detection (92% of all DENV-positive samples). Genotype variation is seen across different sample types. The similarity of CSF and nasopharyngeal DENV subtypes (genotype 1 and 3) suggests a possible correlation between nasopharyngeal replication and neurological complications. The case presented highlights the direct neuropathogenicity of DENV early in the course of infection, and a potential correlation between nasopharyngeal replication and neurological disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
