| Autor: |
Marena, Gabriel Davi, López, Alejandro, Carvalho, Gabriela Corrêa, Marín, María del Pilar, Pérez Ruiz, María Dolores, Pérez-Royo, Jose Manuel, Tormo-Mas, María Ángeles, Bernabé, Patricia, Valentín, Eulogio, Bauab, Taís Maria, Chorilli, Marlus, Pemán, Javier, Ruiz-Gaitán, Alba |
| Předmět: |
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| Zdroj: |
Pathogens; Jul2024, Vol. 13 Issue 7, p549, 15p |
| Abstrakt: |
Candida auris is an emerging, multidrug-resistant yeast that causes systemic infections, mainly in hospitalized or immunosuppressed patients. This pathogen has a high mortality and morbidity rate. This study aims to evaluate the antifungal potential of micafungin (MICA) encapsulated in a nanoemulsion (NEM) against four clades of C. auris and other non-C. auris species. The antifungal potential of MICA and NEM was evaluated by determining mature biofilm inhibition (0.78–50 µg/mL). The antifungal activities of MICA and NEM (5.92 mg/Kg) were evaluated using an in vivo model of Galleria mellonella. The results showed that NEM intensified the antibiofilm action of MICA, especially in 48 h mature biofilms. In vivo results displayed a higher effectiveness of NEM against all clades of C. auris tested, inhibiting the fungal load in the hemolymph and tissues of G. mellonella with a difference of 3 log10. In addition, C. auris infection caused granulomas surrounded by hemocytes, mainly at the lower and upper ends. Conversely, C. albicans developed pseudohyphae, biofilms, filaments, and chlamydospores. In conclusion, encapsulation of MICA in a nanoemulsion enhances its antifungal activity against mature biofilms of C. auris. This strategy may be considered a therapeutic approach for the control of infections and the dissemination of this new global health threat. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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