ACOT7, a candidate and novel serum biomarker of Alzheimer's disease.
Autor: | Jintao Wang, Yong Feng, Yingni Sun |
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Předmět: |
ALZHEIMER'S disease risk factors
ALZHEIMER'S disease diagnosis BRAIN anatomy RISK assessment BIOLOGICAL models PREDICTIVE tests PREDICTION models RESEARCH funding T-test (Statistics) DATA analysis RECEIVER operating characteristic curves BLOOD collection ENZYME-linked immunosorbent assay DESCRIPTIVE statistics MANN Whitney U Test ESTERASES GENE expression MICE ANIMAL experimentation RESEARCH WESTERN immunoblotting CASE-control method STATISTICS GERIATRIC Depression Scale DATA analysis software PSYCHOLOGICAL tests COENZYMES AMYLOID beta-protein precursor BIOMARKERS SENSITIVITY & specificity (Statistics) METABOLISM |
Zdroj: | Frontiers in Aging Neuroscience; 2024, p1-8, 8p |
Abstrakt: | Alzheimer's disease (AD) is the most common fatal neurodegenerative disease among the elderly worldwide, characterized by memory and cognitive impairment. The identification of biomarkers for AD is crucial and urgent to facilitate the diagnosis and intervention. The aim of this study was to evaluate the diagnostic value of acyl-Coenzyme A thioesterase 7 (ACOT7) as a serum biomarker for the prediction of AD. In our study, we observed a significant increase in ACOT7 expression in patients (n = 366) with AD and animal (n = 8-12) models of AD, compared to the control group. A significant negative correlation was found between ACOT7 levels and Mini-Mental State Examination (MMSE) scores (r = -0.85; p < 0.001). The analysis of the receiver operating characteristic curve (ROC) showed that the area under the curve (AUC) for ACOT7 was 0.83 (95% confidence intervals: 0.80-0.86). The optimal cut-off point of 62.5 pg./mL was selected with the highest sum of sensitivity and specificity. The diagnostic accuracy of serum ACOT7 for AD was 77% (95% confidence intervals: 72-82%), with a sensitivity of 80% (95% confidence intervals: 75-84%) and a specificity of 74% (95% confidence intervals: 69-79%). Moreover, the ROC analysis showed that the AUC of Aβ |
Databáze: | Complementary Index |
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