Stereoselective Synthesis of Acylethenyl Tetrahydropyridino- and Deazepanopyrrolo[1,2- c ]imidazolidines via Annulation of Cyclic Imines with Acylethynylpyrroles.

Autor:	Oparina, Ludmila A., Belyaeva, Kseniya V., Kolyvanov, Nikita A., Ushakov, Igor A., Sagitova, Elena F., Trofimov, Boris A.
Předmět:	ANNULATION IMIDAZOLIDINES IMINES AZEPINES IMIDAZOPYRIDINES MOIETIES (Chemistry)
Zdroj:	Synthesis; Aug2024, Vol. 56 Issue 15, p2347-2360, 14p
Abstrakt:	A new and efficient strategy for the stereoselective synthesis of tetrahydropyridino- and deazepanopyrrolo[1,2- c ]imidazolidines has been developed. Annulation of acylethynylpyrroles with six- and seven-membered cyclic imines (MeCN/THF, 20–25 °C, 24–72 h) leads to tetrahydropyrrolo[1′,2′:3,4]imidazo[1,2- a ]pyridines and hexahydropyrrolo[1′,2′:3,4]imidazo[1,2- a ]azepines with (E)-acylethenyl moiety in 28–96% yields. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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