| Autor: |
Sooksawat, Dhassida, Boonpech, Worarat, Tipmanee, Varomyalin, Churuangsuk, Chaitong, Srifa, Pemikar, Juncheed, Kantida |
| Předmět: |
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| Zdroj: |
Trends in Sciences; Aug2024, Vol. 21 Issue 8, p1-13, 13p |
| Abstrakt: |
Cancer cells demonstrate enhanced survival owing to the underlying metabolic changes that accelerate tumor growth. Hepatocellular carcinoma (HCC) cells exhibit the Warburg effect, a hallmark of cancer metabolism associated with aberrant proliferation. This review critically assesses the existing obstacles in developing selective type II glucose transporter GLUT-2 inhibitors, examining the inhibition of GLUT-2 by natural extracts and synthesized compounds. Liver cells regulate glucose uptake and release via GLUT-2. Dysregulated GLUT-2 expression in HCC increases glucose absorption and metabolism, thereby fueling tumor growth. Targeting inhibition of GLUT-2 may delay tumor development and improve therapeutic sensitivity by preventing glucose uptake by cancer cells. Natural and synthetic chemicals that specifically limit GLUT-2 activity are promising GLUT-2 inhibitors. GLUT-2 inhibitors must be engineered with precision to specifically target GLUT-2 while avoiding interference with other GLUT functions. Targeted therapy is complicated by difficulties in determining the mechanisms underlying GLUT-2 dysregulation in various malignancies. New HCC treatments require a deep understanding of GLUT-2 and cancer metabolism as well as advances in pharmacological research and development. Conclusively, the targeting of GLUT-2 is a novel therapeutic strategy for HCC. Understanding the intricate role of GLUT-2 in the pathophysiology of HCC may lead to the development of tailored therapies for patients with HCC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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