Researchers from State University of New York (SUNY) Buffalo Detail Research in Streptococcus pneumoniae (Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus...).

Předmět:	STREPTOCOCCUS pneumoniae NEUTROPHILS GRAM-positive bacterial infections STREPTOCOCCUS RESEARCH personnel
Zdroj:	Respiratory Therapeutics Week; 6/25/2024, p923-923, 1p
Abstrakt:	A recent study conducted by researchers from the State University of New York (SUNY) Buffalo focused on Streptococcus pneumoniae, a leading cause of pneumonia in older adults. The study aimed to understand the mechanisms behind the aberrant neutrophil recruitment associated with aging. The researchers found that there was a significant delay in early neutrophil recruitment to the lungs of aged mice following pneumococcal infection. They also discovered that activation of the A1 adenosine receptor signaling in aged mice rescued the early defect in neutrophil migration to the lungs and improved control of bacterial burden. This study suggests that targeting age-driven defects in immune signaling pathways could help improve the response to bacterial pneumonia in older adults. [Extracted from the article]
Databáze:	Complementary Index
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