| Předmět: |
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| Zdroj: |
Cancer Weekly; 6/25/2024, p1972-1972, 1p |
| Abstrakt: |
A patent has been issued to F. Hoffmann-La Roche Inc. for a universal reporter cell assay that can be used to test the specificity of novel antigen binding moieties. The assay combines the assessment of binding to a target antigen with the activation of T cells in response to the antibody-target binding. It is a valuable tool for screening and characterizing antibody binding and functionality in the development of drug candidates. The method involves providing an antigen binding molecule, contacting it with a target cell and a reporter T cell, and determining T cell activation to establish the specificity of the antigen binding moiety. The assay can be used in high-throughput formats and is applicable to a wide variety of cancer cell types. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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