| Abstrakt: |
A recent study conducted by researchers at Kyorin University School of Medicine in Tokyo, Japan, has shed light on the role of ADGRF5, an adhesion G protein-coupled receptor, in maintaining the integrity of the glomerular filtration barrier. The researchers found that ADGRF5 is specifically expressed in the capillary endothelial cells within the glomerulus. When ADGRF5 was deleted in mice, it resulted in albuminuria, impaired kidney function, and morphological defects in the glomeruli. The study also revealed that the loss of ADGRF5 altered gene expression in glomerular endothelial cells and disrupted the structure and permselectivity of the glomerular filtration barrier. [Extracted from the article] |
