| Autor: |
Sandiumenge, Alberto, Bello, Irene, Coll-Torres, Elisabeth, Gomez-Brey, Aroa, Franco-Jarava, Clara, Miñambres, Eduardo, Pérez-Redondo, Marina, Mosteiro, Fernando, Sánchez-Moreno, Laura, Crowley, Silvana, Fieira, Eva, Suberviola, Borja, Alan Mazo, Cristopher, Agustí, Alvar, Pont, Teresa |
| Předmět: |
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| Zdroj: |
Transplant International; 2024, p1-10, 10p |
| Abstrakt: |
Brain death triggers a systemic inflammatory response. Whether systemic inflammation is different in lung donors after brain- (DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-α in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients. Relevant clinical information and blood samples were collected before/during lung retrieval in donors and before/during/after (24, 48 and 72 h) LT in recipients. Incidence of PGD and short-term mortality after LT was recorded. Plasma levels of all determined cytokines were numerically higher in DBD than in DCD donors and reached statistical significance for IL-6, IL-10 and IL-8. In recipients with PGD the donor’s plasma levels of TNF-α were higher. The postoperative mortality rate was very low and similar in both groups. DBD is associated with higher systemic inflammation than DCD donors, and higher TNF-α plasma levels in donors are associated with a higher incidence of PGD [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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