| Autor: |
Mikame, Yu, Maekawa, Nagisa, Kimura, Soichiro, Nakao, Juki, Yamayoshi, Asako |
| Předmět: |
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| Zdroj: |
Synlett; Jul2024, Vol. 35 Issue 11, p1285-1290, 6p |
| Abstrakt: |
This article explores the synthesis of methyl-substituted psoralen derivatives and their potential for DNA photocrosslinking. Psoralen is a natural compound used in skin disease treatment, but it can have toxic and mutagenic effects. The researchers aimed to enhance the reactivity of psoralen and control crosslinked product formation by adding methyl substituents at specific positions. They developed a synthetic method for creating psoralen derivatives and tested their photocrosslinking abilities with DNA. The results showed that the presence of methyl substituents reduced the formation of harmful diadducts. The article suggests further research to explore different psoralen derivatives and investigate their photocrosslinking properties. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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