| Abstrakt: |
A study conducted at Yanbian University Hospital in Jilin, China, has found that chronic psychosocial stress can lead to metabolic disorders. The study focused on the role of dipeptidyl peptidase-4 (DPP4) and cysteinyl cathepsin K (CTSK) in stress-related adipocyte differentiation. The researchers discovered that increased DPP4 activity in mice under chronic stress conditions negatively regulated the glucagon-like peptide-1 (GLP-1)/adiponectin-CTSK axis, leading to harmful changes in adipose tissue. However, DPP4 deletion and GLP-1 receptor activation were found to reverse these effects, suggesting that the DPP4/GLP-1 and adiponectin/CTSK axes could be potential therapeutic targets for individuals with stress-related metabolic disorders. [Extracted from the article] |
