| Autor: |
Scheunchen, M., Gräbner, C., Kuckhahn, A., Distler, J., Spriewald, B., Ramsperger-Gleixner, M., Weyand, M., Heim, C. |
| Předmět: |
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| Zdroj: |
Thoracic & Cardiovascular Surgeon; 2024 Supplement1, Vol. 72, pS1-S68, 68p |
| Abstrakt: |
This article discusses the potential of blocking the Notch and Hedgehog signaling pathways to reduce neointima formation in a murine aortic transplant model. Cardiac allograft vasculopathy (CAV) is a major issue following heart transplantation, characterized by the formation of a neointima in the coronary vessels. The study conducted on mice showed that both LDE225 and DAPT, inhibitors of the Hedgehog and Notch pathways respectively, significantly reduced neointima formation compared to control groups. These findings suggest that blocking these pathways could be a promising approach to prevent CAV. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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